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How CBD Affects the Endocannabinoid System?

If you’re a CBD user, then this blog can be useful for you. Here, you’ll get a clear idea of how CBD affects the endocannabinoid system in the body.

Table of Contents

  1. . What is endocannabinoid system?
  2. How CBD Affects the Endocannabinoid System?
  3. The Functioning of CBD and Receptors
  4. Conclusion

What is Endocannabinoid System?

The endocannabinoid system is essential for several body functions. This system responds to the endogenous cannabinoids formed in the body.

To know more about it, click here.

How CBD Affects the Endocannabinoid System?

According to the research, ECS has the efficiency to give response to cannabinoids. This includes cannabidiol or CBD as well.

As per the National Institute of Health, interaction of the endocannabinoid system and cannabidiol could be helpful for dealing with a wide range of health problems.

These health problems include:

  • Acne
  • Nausea
  • Psoriasis
  • Pain
  • Inflammation
  • Epilepsy
  • Diabetes
  • Irritable Bowel Syndrome
  • Heart problems

When it comes to cannabidiol, scientists are saying that CBD works by activating the endocannabinoid receptors found in the ECS. However, it doesn’t trigger the receptors directly; instead, it modifies the ability of receptors to bind with the cannabinoids.

The two main receptors are CB1 and CB2.

Next, let’s check how the interaction of cannabidiol and cannabinoid receptors can help humans.

The Functioning of CBD and Receptors

CB1 Receptors

These are present mainly in the brain, connective tissues, gonads, central nervous system, etc.

As per the studies, if cannabidiol activates the CB1 receptors, then it can lead to:

  • Lowering blood pressure
  • Reducing anxiety
  • Reducing depression
  • Lessening inflammation in the intestinal
  • Lessening paranoia and fear

CB2 Receptors

These are existing mainly in the thymus, spleen, and tonsils. Additionally, they also exists in the immune cells.

The modification in the functioning of these receptors can play a significant role in several health issues. This includes neurodegenerative, cardiovascular, functioning of kidney and liver, cancer, gastrointestinal, autoimmune, etc.

Moreover, the activation of these receptors destroys the beta-amyloid protein with the help of macrophages. This, in turn, may help Alzheimer’s patients as this is the main compound present in the brains of Alzheimer’s patients.


Through this article, we made an effort to make you understand the effect of CBD in the endocannabinoid system. We believe that now you’re clear on how cannabidiol works with the ECS of your body.

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